ORG::PROFILE
Pre-seed TechBio · Computational Tissue Reprogramming
SYS::MISSION
Fibrosis — the pathological scarring of tissue — is the endpoint of severe burns, deep skin trauma, and chronic inflammatory damage. Current treatments address symptoms. StateZero targets the root cause at the transcriptomic level.
Our platform models biological tissue as a programmable state-space. We profile fibrotic disease states (T_pre) and define a healthy fetal regenerative blueprint (T_post), then computationally solve for the minimal perturbation vector that collapses the fibrotic trajectory back to the target — without slow, traditional wet-lab trial and error.
The result is SZ-01: a computationally validated topical polypharmacology cocktail achieving an 89% in-silico cell-state reversal score against hypertrophic scar and deep burn profiles.
89%
In-silico cell-state reversal (SZ-01)
3
Pipeline assets in development
1
Validated lead therapeutic candidate
∞
Fibrotic trajectories modelled
TEAM::LEADERSHIP
Pavel Abramau
CEO / Lead AI Architect
Remote · EU
Architect of the StateZero computational engine. Designed the full latent-space transcriptomics pipeline — from scRNA-seq ingestion and LINCS perturbation screening to Virtual CRISPR simulation and the Transcriptomic-to-Fingerprint Encoder. Thin-client SSH architecture connecting a lightweight Mac to a 1 TB Ryzen execution core.
Prof. Paweł Sachadyn
Scientific Lead · Biomedical
Gdańsk University of Technology
Full Professor of Biotechnology at GUT-PB. Specialist in molecular biology, genetic engineering, and regenerative tissue research. Provides scientific oversight on the biological framework — from T_pre disease-state profiling to fetal T_post target blueprint validation and wet-lab translation strategy.